Pyritinol

Pyritinol is a counterpart to Vitamin B6 which has been prescribed in Europe to treat a wide variety of mental disorders.

pyritinol

Benefits:

  • Pyritinol acts as an antioxidant. Specifically, it is known to protect the brain against hydroxyl radicals. These radicals can cause damage to red blood cells, DNA, lipids, and proteins. [3]
  • It enhances nerve activity in the locus coeruleus.  This part of the brain plays an important role in regulating panic, anxiety, and depression. It also releases norepinephrine which acts to increase working memory. [4]
  • Pyritinol enhances the brain’s ability to transport glucose through the blood-brain barrier. Glucose is our body and brain’s key source of energy. Higher levels of glucose increase many psychological processes including mental energy, concentration, decision making, and self-control. [5]
  • Enhances the movement and sustainability of neutrophils. Neutrophils are the most common form of white blood cells and act as the primary defense in the body against infection. As these white blood cells work they damage themselves ultimately resulting in self-destruction. Pyritinol not only helps migrate these white blood cells but also helps sustain them by pro-longing their self-destruct process. [6]

What Is Pyritinol?

Pyritinol is a semi-natural, water soluble counterpart to vitamin B6. It was first manufactured by Merck Laboratories in 1961. Merck created Pyritinol by bonding two viatminB6 compounds together. Since its creation, this nootropic has been prescribed in several countries for cognitive and learning disorders

It is officially approved for “symptomatic treatment of chronically impaired brain function in dementia syndromes” in European countries including Germany, Greece, Portugal, Italy, France, and Austria. Pyritinol is widely advertised as a nootropic and sold online or over-the-counter in many other countries.

Pyritinol Dosage Information

The most commonly recommended dosage is 100mg taken 1-3 times per day although doses as high as 1,600mg have been administered safely during studies. Tablets should not be taken with meals.  It advised not to exceed 300mg per day without first consulting your physician.

How Does Pyritinol Work?

  1. Pyritinol acts as an antioxidant. Specifically, it is known to protect the brain against hydroxyl radicals. These radicals can cause damage to red blood cells, DNA, lipids, and proteins. [3]
  2. It enhances nerve activity in the locus coeruleus.  This part of the brain plays an important role in regulating panic, anxiety, and depression. It also releases norepinephrine which acts to increase working memory. [4]
  3. Pyritinol enhances the brain’s ability to transport glucose through the blood-brain barrier. Glucose is our body and brain’s key source of energy. Higher levels of glucose increase many psychological processes including mental energy, concentration, decision making, and self-control. [5]
  4. Enhances the movement and sustainability of neutrophils. Neutrophils are the most common form of white blood cells and act as the primary defense in the body against infection. As these white blood cells work they damage themselves ultimately resulting in self-destruction. Pyritinol not only helps migrate these white blood cells but also helps sustain them by pro-longing their self-destruct process. [6]

Safety and Side Effects of Pyritinol

Pyritinol is generally well-tolerated and comes with few side effects. Minor reported side effects include nausea, headache, and skin reaction.

More serious side effects were noted during the treatment of rheumatoid arthritis. These side effects were noted as not causing serious health risks and were reversible. Adverse effects cause during these trials affected the blood, kidney, and liver. For these reasons, using Pyritinol to treat rheumatoid arthritis should only be conducted under physician supervision.

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Pyritinol FAQ

Below are some of the most commonly asked questions about Pyritinol. If you have a question that’s not on this list, send it to us at questions@whatarenootropics.com and we will answer it for you.

Should I Use Pyritinol?

What Are Some Noteable Studies Performed on Pyritinol?

Cited Studies

1. Hindmarch I, Coleston DM, Kerr JS (1990). “Psychopharmacological effects of pyritinol in normal volunteers”. Neuropsychobiology 24 (3): 159–64. doi:10.1159/000119478. PMID 2135070.

2. Wiese JG, Shlipak MG, Browner WS (June 2000). “The alcohol hangover”. Annals of Internal Medicine 132 (11): 897–902. PMID 10836917. http://www.annals.org/cgi/pmidlookup?view=long&pmid=10836917.

3. McDonnell, G; Russell, AD (1999). “Antiseptics and Disinfectants: Activity, Action, and Resistance”. Clinical microbiology reviews 12 (1): 147–79. PMC 88911. PMID 9880479. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88911.

4. Ramos BP, Arnsten AF. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther 2007; 113: 523-536.

5. [Fairclough, Stephen H.; Houston, Kim (2004), “A metabolic measure of mental effort”, Biol. Psychol. 66 (2): 177–90, doi:10.1016/j.biopsycho.2003.10.001, PMID 15041139

6. http://www.antiaging-systems.com/175-pyritinol

7. http://www.ncbi.nlm.nih.gov/pubmed/2687355

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