Pterostilbene is a substance that naturally occurs in grapes and berries. While it has long been renowned for it’s cardiovascular benefits, research has shown it to also be a nootropic.



  • Lowers cholesterol and fights heart disease [2][3]
  • Slows the cognitive decline and motor-skill decline brought on by aging [5]
  • Has anti-oxidant and cancer-fighting properties [6]

What Is Pterostilbene?

Pterostilbene is a naturally occurring substance found in blueberries and grapes. It is classified as a phytoalexin meaning plants produce it to fight off various types of infections. It is well known for having various health benefits including reduction of cognitive decline due to aging, lowering cholesterol levels, and anti-cancer effects.  Agnes Rimando, a chemist at ARS’s Natural Poducts Utilization Research Laboratory in Oxford, Mississippi stated:

“The more we study Pterostilbene, the more we see its huge potential in the human health field”

Pterostilbene Dosage Information

The suggested daily dosage is between 100 to 250mg for adults. You should reach these amounts by taking a single 50 to 125mg capsule twice daily. [7]

How Does Pterostilbene Work?

Pterostilbene is known to bind to the PPAR-alpha receptor. This receptor plays a major part in the regulation of lipid metabolism in the liver and activation of this receptor promotes catabolism of fatty acids. [1]

This nootropic is known to inhibit the enzyme cytochrome P-450 which is known to activate various chemical carcinogens giving Pterostilbene anti-cancer properties.

Safety and Side Effects of Pterostilbene

This nootropic is regarded as being completely safe and there have been no reported side effects.


Pterostilbene FAQ

Below are some of the most commonly asked questions about Pterostilbene. If you have a question that’s not on this list, send it to us at and we will answer it for you.

Should I Use Pterostilbene?

What Are Some Notable Pterostilbene Studies?

Cited Studies

1.  Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. (June 1999). “Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.”. J Clin Invest. 103 (11): 1489–98. doi:10.1172/JCI6223. PMC 408372. PMID 10359558.



4. Pari L, Satheesh MA (July 2006). “Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats”. Life Sciences 79 (7): 641–5. doi:10.1016/j.lfs.2006.02.036. PMID 16616938

5.  Braslavsky, Andrea, “Blueberries May Be King of the Hill for Those Over the Hill,” WebMD Medical News, Sept. 16, 1999, retrieved December 29, 2006.



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