Picamilon

Picamilon is a prodrug of GABA which crosses the blood brain barrier more easily. It provides many of the same benefits of GABA but may be more effective.

picamilon

Benefits:

  • Produces an anxiolytic response which decreases anxiety. [3]
  • Used to treat Asthenia, which results in increase muscle strength. [2]
  • Enhances learning and memory. [1]
  • Used to treat depression. [2]
  • Effective for treatment of migraine and other headaches. [5]
  • Helpful with the misuse of alcohol and treatment of hangovers. [2]
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What Is Picamilon?

Picamilon was developed in 1969 in the Soviet Union by the All-Union Vitamins scientific research institute. Since then it has been studied further in Japan and Russia as a prodrug of GABA. Currently, picamilon is sold in the United States as a dietary supplement and is sold in Russia as an “over-the-counter” drug.

Picamilon Dosage Information

Different results have been noted at different dosages. Lower dosages of 50mg taken three times a day have been shown to achieve a tranquilizing effect reducing overall anxiety. When one increases the dosage to 100mg taken three times a day nutritional stimulation and increased endurance begin to occur. It is recommended that if someone were to take picamilon to assist with boy-building that they take at least 100mg three times a day. Because of picamilon’s ability to cross the blood-brain barrier effects are usually felt within 30 minutes to an hour after consumption. [1]

How Does Picamilon Work?

Picamilon is another nootropic with the ability to cross the blood-brain barrier. Once it has crossed the blood-brain barrier it then splits into GABA (the chief inhibitory neurotransmitter in the central nervous system) and niacin by the process of hydrolysis. The release of GABA activates your GABA receptors. This leads to a decrease in anxiety. [3] The niacin acts as a powerful vasodilator. [4] This means that niacin is able to widen the blood vessels by relaxing the smooth muscle cells within the vessel walls. This widening occurs particularly in arteries and larger veins.

Safety and Side Effects of Picamilon

Picamilon has an extremely low toxicity and is known to be very safe. There are no known allergenic, or carcinogenic effects. Some common side effects include nausea, dizziness, and rashes. It is recommended that someone not take this product without first consulting their physician if they are pregnant or lactating. It is also recommended the one not use this product if one suffers from renal disease or has a family history of stroke. [1]

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Picamilon FAQ

Below are some of the most commonly asked questions about Picamilon. If you have a question that’s not on this list, send it to us at questions@whatarenootropics.com and we will answer it for you.

Should I Use Picamilon?

What Are Some Interesting Picamilon Studies?

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Cited Studies

1. http://www.dr-bob.org/babble/alter/20040815/msgs/384573.html

2. http://translate.google.com/translate?js=n&prev=_t&hl=en&ie=UTF-8&layout=2&eotf=1&sl=auto&tl=en&u=http%3A%2F%2Fwww.rlsnet.ru%2Ftn_index_id_5545.htm

3. Shephard RA (June 1987). “Behavioral effects of GABA agonists in relation to anxiety and benzodiazepine action”. Life Sci. 40 (25): 2429–36. doi:10.1016/0024-3205(87)90758-2. PMID 2884549.

4. Gille A, Bodor ET, Ahmed K, Offermanns S (2008). “Nicotinic acid: pharmacological effects and mechanisms of action”. Annu. Rev. Pharmacol. Toxicol. 48: 79–106. doi:10.1146/annurev.pharmtox.48.113006.094746. PMID 17705685

5. Prousky J, Seely D (2005). “The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature”. Nutr J 4: 3. doi:10.1186/1475-2891-4-3. PMC 548511. PMID 15673472

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