Noopept

Noopept is a nootropic belonging to the ‘racetam family which is commonly used in Russia and nearby countries. It is reported to be over 1000 times stronger than Piracetam.

aniracetam

Key Benefits:

  • Enhances memory, recall, and learning [1][2][3][4][5]
  • Is neuroprotective [2][3][4][5]
  • Improves NGF [4]
  • Provides an anti-oxidant effect [11]
  • Improves the effectiveness of brain training games such as the ones offered by Lumosity.
  • Improves communication between the left and right brain hemispheres. [11]

Noopept Overview

Noopept is a ‘racetamic nootropic and is similar in structure and mechanism of action to piracetam. It shares many of the same benefits as piracetam, however is between 1000 – 5000 times more potent. [1] This doesn’t mean its benefits are that much more pronounced than Piracetam, just that it has a better binding affinity for the same receptors. This is why a much smaller dose of Noopept is needed when compared to other ‘racetams.

Developed in Russia, Noopept is commonly prescribed both in Russia and in neightboring countries as a nootropic remedy. It is used there both to treat certain neurological disorders and to improve cognition in healthy people. It has just recently begun to gain popularity overseas.

Noopept Benefits

  • Many studies have tests have shown Noopept to be effective at improving memory, learning, and recall. [1][2][3][4][5] Unlike piracetam which only facilitates the early stages of memory formation, noopept improves both the stage of memory consolidation and also the steps of memory retrieval. [10] This suggests it is a far more effective memory enhancer than piracetam.
  • Research has shown Noopept to be very neuroprotective. [2][3][4][5] In one study it successfully prevented brain damage due to oxidative stress as well as apoptosis in human neurons.
  • Has been shown to increase levels of Nerve growth factor(NGF) and Brain-derived neurotrophic factor (BDNF) in rats. [4] NGF is responsible for the growth and survival of certain kinds of neurons. BDNF is a similar growth factor and helps keep existing neurons in good health as well as encouraging growth and specialization of new neurons and synapses. BDNF in particular is especially important for long-term memory. [8] If Noopept also causes increases in levels of these growth factors in humans it could prove an extremely valuable long-term supplement for overall intelligence and cognitive health.
  • Noopept helps catalyze the formation of associative connections between the left and right hemispheres of the brain. [11] Studies have shown this can result in improved memory, recall, and creativity.
  • Acts as an anti-oxidant and has an atagonistic effect on excess calcium. [11]
  • Helps reverse damage dealt to cognitive functions due to brain injury, ischemia, and prenatal damage. [11]
  • Anecdotal evidence suggests Noopept can improve drive and motivation, though there is little research done on these claims.

Medical Uses

  • Studies have shown that it may be an effective treatment for Alzheimer’s disease [3]
  • Research suggests Noopept may be an effectve theraputic treatment for mental retardation and neurodegenerative disorders. [2]
  • May be effective at bolstering the immune system [7]
  • Can prevent certain types of amnesia [11]
  • Provides a theraputic effect to patients experiencing organic disorders of the central nervous system. [11]
  • Can reduce the severity of some headaches [11]

How Does Noopept Work?

After being consumed, Noopept is absorbed through the GI tract and reaches maximum concentration within the brain in about 15 minutes. It has a very high oral bioavailability and easily penetrates the blood-brain barrier. [6] This means that almost all of the Noopept you take orally will make it into systemic circulation, and will reach the brain where it can provide it’s cognitive enhancing effects.

It works in a manner very similar to piracetam, and reacts strongly with glutamatergic AMPA receptors. Noopept binds to these receptors and allow glutamate to move between brain cells more easily.[9] This is what causes it to increase synaptic plasticity and is partially responsible for its cognitive enhancing effects.

Dosing Noopept

Like piracetam, Noopept will provide the greatest benefits when taken once or twice daily for prolonged periods of time. It is generally recommended that you take 10 – 20 mg of Noopept one to three times a day. From this starting point, you can adjust your dose up or down as necessary.

Because of the relatively low doses at which Noopept should be taken, it is recommended that you purchase a milligram scale in order to ensure you take a consistent dose each time.

Safety and Side Effects of Noopept

Like other ‘racetams, Noopept is extremely non-toxic and has few side effects when taken at normal doses. Studies have shown it to deal no damage to internal organs and to have no immunotoxic or mutagenic properties. [11] Rare allergic reactions to it have been observed however, and it has been shown to occasionally cause an increase in blood pressure in people suffering from hypertension. [11] At very high doses, irritability and sedation have been reported.

Anecdotal evidence suggests that Noopept could increase the potency of stimulants such as Amphetamine. However it is not recommended that it be used for this purpose as it is not known whether the combination is harmful or if it could result in excitotoxicity.

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Cited Sources
[1] The effects of piracetam and its novel peptide analogue GVS-111 on neuronal voltage-gated calcium and potassium channels.
http://www.ncbi.nlm.nih.gov/pubmed/9195198

[2] GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons.
http://www.ncbi.nlm.nih.gov/pubmed/12711349

[3]The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model.
http://www.ncbi.nlm.nih.gov/pubmed/17092975

[4]Noopept stimulates the expression of NGF and BDNF in rat hippocampus.
http://www.ncbi.nlm.nih.gov/pubmed/19240853

[5] Impairment of learning and memory after photothrombosis of the prefrontal cortex in rat brain: effects of Noopept.
http://www.ncbi.nlm.nih.gov/pubmed/12660828

[6] Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration.
http://www.ncbi.nlm.nih.gov/pubmed/10977920

[7] Immunopharmacological properties of noopept.
http://www.ncbi.nlm.nih.gov/pubmed/18256750

[8] BDNF is essential to promote persistence of long-term memory storage
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268201/?tool=pmcentrez

[9] Studying specific effects of nootropic drugs on glutamate receptors in the rat brain
http://www.ncbi.nlm.nih.gov/pubmed/21476267

[10] The original novel nootropic and neuroprotective agent noopept
http://www.ncbi.nlm.nih.gov/pubmed/12596521

[11] Noopept Manufacturer’s Insert
https://docs.google.com/viewer?a=v&q=cache:ReCo53WsK48J:photos.imageevent.com/diydefense/awakebrain/NoopeptInsertEnglish.pdf

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